Arden Moscati

Associate Researcher

Arden is a research scientist at the Charles Bronfman Institute for Personalized Medicine, and the Center for Genomic Health. Among other interests, he explores etiological overlap between traits and disease entities that are often conceived as distinct constructs, for instance the study of comorbidity between multiple disorders. Due to the close relationship between the evolutionary history of human populations and their present-day traits and disease burden, he is beginning to apply a variety of population genetic approaches to investigate the differences and similarities between groups in diverse populations. One of these efforts is inferring the continental and local ancestry of individuals in NHGRI’s Genome Sequencing Program. He was trained at the Virginia Institute for Psychiatric and Behavioral genetics, in which disciplines you’ll never guess.


Genes, Roommates, and Residence Halls: A Multidimensional Study of the Role of Peer Drinking on College Students’ Alcohol Use.
Smith RL, Salvatore JE, Aliev F, Neale Z, Barr P; Spit for Science Working Group, Dick DM.
Alcohol Clin Exp Res. 2019 Apr 29. doi: 10.1111/acer.14037. [Epub ahead of print]
PMID: 31034622

Pathway-based polygene risk for severe depression implicates drug metabolism in CONVERGE.
Docherty AR, Moscati A, Bigdeli TB, Edwards AC, Peterson RE, Adkins DE, Anderson JS, Flint J, Kendler KS, Bacanu SA.
Psychol Med. 2019 Apr 2:1-6. doi: 10.1017/S0033291719000618. [Epub ahead of print]
PMID: 30935430

Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity.
Dallner OS, Marinis JM, Lu YH, Birsoy K, Werner E, Fayzikhodjaeva G, Dill BD, Molina H, Moscati A, Kutalik Z, Marques-Vidal P, Kilpeläinen TO, Grarup N, Linneberg A, Zhang Y, Vaughan R, Loos RJF, Lazar MA, Friedman JM.
Nat Med. 2019 Mar;25(3):507-516. doi: 10.1038/s41591-019-0370-1. Epub 2019 Mar 6.
PMID: 30842678

Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response.
Hu W, Jiang C, Guan D, Dierickx P, Zhang R, Moscati A, Nadkarni GN, Steger DJ, Loos RJF, Hu C, Jia W, Soccio RE, Lazar MA.
Cell Stem Cell. 2019 Feb 7;24(2):299-308.e6. doi: 10.1016/j.stem.2018.11.018. Epub 2019 Jan 10.
PMID: 30639037

Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans.
Polfus LM, Raffield LM, Wheeler MM, Tracy RP, Lange LA, Lettre G, Miller A, Correa A, Bowler RP, Bis JC, Salimi S, Jenny NS, Pankratz N, Wang B, Preuss MH, Zhou L, Moscati A, Nadkarni GN, Loos RJF, Zhong X, Li B, Johnsen JM, Nickerson DA, Reiner AP, Auer PL; NHLBI Trans-Omics for Precision Medicine Consortium.
Hum Mol Genet. 2019 Feb 1;28(3):515-523. doi: 10.1093/hmg/ddy360.
PMID: 30307499

A common TCN1 loss-of-function variant is associated with lower vitamin B12 concentration in African Americans.
Hu Y, Raffield LM, Polfus LM, Moscati A, Nadkarni G, Preuss MH, Zhong X, Wei Q, Rich SS, Li Y, Wilson JG, Correa A, Loos RJF, Li B, Auer PL, Reiner AP; NHLBI Trans-Omics for Precision Medicine Consortium.
Blood. 2018 Jun 21;131(25):2859-2863. doi: 10.1182/blood-2018-03-841023. Epub 2018 May 15. No abstract available.
PMID: 29764838
Similar articles

Polygenic prediction of the phenome, across ancestry, in emerging adulthood.
Docherty AR, Moscati A, Dick D, Savage JE, Salvatore JE, Cooke M, Aliev F, Moore AA, Edwards AC, Riley BP, Adkins DE, Peterson R, Webb BT, Bacanu SA, Kendler KS.
Psychol Med. 2018 Aug;48(11):1814-1823. doi: 10.1017/S0033291717003312. Epub 2017 Nov 27.
PMID: 29173193

Cross-Lagged Analysis of Interplay Between Differential Traits in Sibling Pairs: Validation and Application to Parenting Behavior and ADHD Symptomatology.
Moscati A, Verhulst B, McKee K, Silberg J, Eaves L.
Behav Genet. 2018 Jan;48(1):22-33. doi: 10.1007/s10519-017-9882-y. Epub 2017 Nov 17.
PMID: 29150722

Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women.
Edwards AC, Docherty AR, Moscati A, Bigdeli TB, Peterson RE, Webb BT, Bacanu SA, Hettema JM, Flint J, Kendler KS.
Psychol Med. 2018 Apr;48(5):777-789. doi: 10.1017/S0033291717002148. Epub 2017 Oct 3.
PMID: 28969721

Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.
Adkins AE, Hack LM, Bigdeli TB, Williamson VS, McMichael GO, Mamdani M, Edwards AC, Aliev F, Chan RF, Bhandari P, Raabe RC, Alaimo JT, Blackwell GG, Moscati A, Poland RS, Rood B, Patterson DG, Walsh D; Collaborative Study of the Genetics of Alcoholism Consortium, Whitfield JB, Zhu G, Montgomery GW, Henders AK, Martin NG, Heath AC, Madden PAF, Frank J, Ridinger M, Wodarz N, Soyka M, Zill P, Ising M, Nöthen MM, Kiefer F, Rietschel M; German Study of the Genetics of Addiction Consortium, Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer LA, Maher BS, Prescott CA, Dick DM, Bacanu SA, Mathies LD, Davies AG, Vladimirov VI, Grotewiel M, Bowers MS, Bettinger JC, Webb BT, Miles MF, Kendler KS, Riley BP.
Alcohol Clin Exp Res. 2017 May;41(5):911-928. doi: 10.1111/acer.13362. Epub 2017 Mar 30.
PMID: 28226201

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