GenomeWeb

June 19, 2019

NEW YORK (GenomeWeb) – A team led by investigators at the Fred Hutchinson Cancer Research Center, Icahn School of Medicine at Mount Sinai, and the University of North Carolina at Chapel Hill demonstrated that the common genetic risk variants implicated in human traits and diseases — and the extent of heritability explained by them — can differ significantly across populations with different ancestral backgrounds.

Those involved in the study argued that such realizations need to be taken into account when developing genomics-based risk assessment or treatment strategies to meet the healthcare needs of diverse human populations, while narrowing existing healthcare gaps.

“Because the availability of non-European genomic data is limited, existing clinical therapies may disproportionately benefit those of European descent, further widening the health disparities gap,” co-senior author Eimear Kenny, a genomic health, personalized medicine, and psychiatric genomics researcher at Icahn School of Medicine, said in a statement.

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