BRCA2 Fact Sheet
Cancer Risk Estimates
|Cancer Type||Average lifetime risk||Risk by age 70 with BRCA2 variant*|
|Male breast||<0.1%||up to 8.9%|
*Risk estimates are from GeneReviews, and may vary amongst different studies.
Medical recommendations for early detection and prevention of cancer include:
- Breast self-exam starting at age 18
- Clinical breast exam starting at age 25, every 6-12 months
- Annual breast MRI with contrast starting at age 25
- Annual breast MRI with contrast and mammography starting at age 30
- Consideration of risk-reducing mastectomy
- Options for breast cancer risk-reduction medications like tamoxifen
Male breast: Breast self-exam and clinical breast exam starting at age 35
- Risk-reducing removal of ovaries and fallopian tubes (salpingo-oophorectomy) is recommended, typically by age 35-40 and upon completion of childbearing
- Transvaginal ultrasound and CA-125 testing starting at age 30-35
- Options for ovarian cancer risk-reduction medications like birth control pills
Prostate: Prostate cancer screening starting at age 45, including annual digital rectal examination and PSA testing.
Pancreatic: There are no specific recommendations. Screening should be individualized based on your family history of pancreatic cancer.
Melanoma: Skin exam by a dermatologist.
Recommendations may be individualized based on your personal and family history of these cancer types. Speak to your doctor about what options are right for you.
For More Information